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Sharma , S and Lenka, N (2021) Epitranscriptomic Signatures in Neural Development and Disease. In: Epitranscriptomics,. RNA Technologies book series (RNATECHN, volume 12), 12 . Springer, pp. 79-120.

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Epitranscriptomics, reminiscent of RNA epigenetics, involves post-transcriptional modifications occurring across coding and non-coding RNAs. Emergence of epitranscriptomic regulatory machinery underlying various developmental processes has facilitated exploring the intricacies involved during the same. Recent advancements in the field have led to the identification of more than 160 RNA modifications reflecting epitranscriptome dynamism. Undoubtedly, this has added another layer of fine-tuned regulation to the existing gene regulatory machinery. Despite the progress being made in identifying the epitranscriptomic signature and the players involved, a concrete understanding on their distribution and functional relevance during mammalian development and cell fate decision still remains elusive. In fact, evidences are also emerging pertaining to aberrant RNA modifications and their association with various developmental defects and diseases, including that of cancer. Brain, among the vital organs has been reported to be sensitive to epitranscriptomic modifications, where RNA modifications do have a key role to play in modulating various developmental and physiological aspects ranging generation of neurons and glial cells, synaptic transmission, learning, and memory. In addition, those have also been shown to be contributing to tumour heterogeneity, tumour progression, and suppression. In this chapter, we shall be discussing about the current status on epitranscriptomic machinery operational during neural development and its deregulation manifesting neurological disorders and cancer with special emphasis on methylation of adenine and cytosine bases at position 6 and 5, respectively.

Item Type: Book Section
Depositing User: Mr. Rameshwar Nema
Date Deposited: 18 Nov 2021 11:59
Last Modified: 18 Nov 2021 11:59
URI: http://nccs.sciencecentral.in/id/eprint/1011

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