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Choksi , A and Parulekar, A and Pant, R and Shah, VK and Nimma, R and Firmal, P and Singh , S and Kundu , GC and Shukla, S (2021) Tumor suppressor SMAR1 regulates PKM alternative splicing by HDAC6-mediated deacetylation of PTBP1. Cancer and Metabolism, 9 (1). p. 16.

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Highly proliferating cancer cells exhibit the Warburg effect by regulation of PKM alternative splicing and promoting the expression of PKM2. Majority of the alternative splicing events are known to occur in the nuclear matrix where various MARBPs actively participate in the alternative splicing events. SMAR1, being a MARBP and an important tumor suppressor, is known to regulate the splicing of various cancer-associated genes. This study focuses on the regulation of PKM alternative splicing and inhibition of the Warburg effect by SMAR1.

Item Type: Article
Subjects: Cancer Biology
Depositing User: Mr. Rameshwar Nema
Date Deposited: 20 Nov 2021 13:28
Last Modified: 26 Nov 2021 11:29
URI: http://nccs.sciencecentral.in/id/eprint/1025

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