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Chakraborty , R. and Thakur , TS. and Chauhan , R. and Manzar, Z. and Das, G. and Mitra, A. (2021) From discovery to approval: A brief history of the compstatin family of complement C3 inhibitors. Clinical Immunology. p. 108785.

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The FDA approval of pegcetacoplan (Empaveli), a PEGylated compstatin-based C3 therapeutic, as a new treatment for paroxysmal nocturnal hemoglobinuria (PNH) marks a milestone in the history of complement drug discovery. Almost 15 years after the approval of the first complement-specific drug for PNH, the anti-C5 antibody eculizumab, a novel class of complement inhibitors with a distinct mechanism of action finally enters the clinic. This landmark decision broadens the spectrum of available complement therapeutics, offering patients with unmet clinical needs or insufficient responses to anti-C5 therapy an alternative treatment option with a broad activity profile. Here we present a brief historical account of this newly approved complement drug, consolidating its approval within the long research record of the compstatin family of peptidic C3 inhibitors.

Item Type: Article
Subjects: Infection and Immunity
Depositing User: Mr. Rameshwar Nema
Date Deposited: 23 Nov 2021 06:19
Last Modified: 23 Nov 2021 06:19
URI: http://nccs.sciencecentral.in/id/eprint/1052

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