Fernandes , SS. and Limaye, LS. and Kale , VP. (2021) Differentiated Cells Derived fromHematopoietic Stem Cells and Their Applications. In: Advances in Experimental Medicine and Biology Book Series. Elsevier Academic Press.

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Abstract

Hematopoietic stem cells (HSCs) and their development are one of the most widely studied model systems in mammals. In adults, HSCs are predominantly found in the bone marrow, from where they maintain homeostasis. Besides bone marrow and mobilized peripheral blood, cord blood is also being used as an alternate allogenic source of transplantable HSCs. HSCs from both autologous and allogenic sources are being applied for the treatment of various conditions like blood cancers, anemia, etc. HSCs can further differentiate to mature blood cells. Differentiation process of HSCs is being extensively studied so as to obtain a large number of pure populations of various differentiated cells in vitro so that they can be taken up for clinical trials. The ability to generate sufficient quantity of clinical-grade specialized blood cells in vitro would take the field of hematology a step ahead in translational medicine.

Item Type:	Book Section
Subjects:	Stem Cell Biology
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	24 Nov 2021 11:10
Last Modified:	24 Nov 2021 11:10
URI:	http://nccs.sciencecentral.in/id/eprint/1083

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