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Zutshi , S. and Kumar, S. and Chauhan , P. and Saha, B. (2021) Revisiting the Principles of Designing a Vaccine. In: Vaccine Design. Methods in Molecular Biology book series (MIMB, volume 2410), 2410 . Springer, pp. 57-91.

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Immune principles formulated by Jenner, Pasteur, and early immunologists served as fundamental propositions for vaccine discovery against many dreadful pathogens. However, decisive success in the form of an efficacious vaccine still eludes for diseases such as tuberculosis, leishmaniasis, and trypanosomiasis. Several antileishmanial vaccine trials have been undertaken in past decades incorporating live, attenuated, killed, or subunit vaccination, but the goal remains unmet. In light of the above facts, we have to reassess the principles of vaccination by dissecting factors associated with the hosts’ immune response. This chapter discusses the pathogen-associated perturbations at various junctures during the generation of the immune response which inhibits antigenic processing, presentation, or remodels memory T cell repertoire. This can lead to ineffective priming or inappropriate activation of memory T cells during challenge infection. Thus, despite a protective primary response, vaccine failure can occur due to altered immune environments in the presence of pathogens.

Item Type: Book Section
Subjects: Infection and Immunity
Depositing User: Mr. Rameshwar Nema
Date Deposited: 14 Feb 2022 09:45
Last Modified: 14 Feb 2022 09:45
URI: http://nccs.sciencecentral.in/id/eprint/1113

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