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Radharani , NNV and Yadav, AS and Nimma , R and Kumar, TVS and Bulbule , A and Chanukuppa, V and Kumar, D and Patnaik , S and Rapole, S and Kundu , GC (2022) Tumor associated macrophage derived IL-6 enriches cancer stem cell population and promotes breat tumor progression via stat-3 pathway. Cancer Cell International, 22 (122). pp. 1-25.

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Abstract Background Cancer stem cells (CSCs) play crucial role in tumor progression, drug resistance and relapse in various cancers. CSC niche is comprised of various stromal cell types including Tumor-associated macrophages (TAMs). Extrinsic ques derived from these cells help in maintenance of CSC phenotype. TAMs have versatile roles in tumor progression however their function in enrichment of CSC is poorly explored. Methods Mouse macrophages (RAW264.7) cells were activated by interaction with conditioned media (CM) of murine breast cancer cells (4T1) into TAMs and the effect of activated macrophage (TAM) derived factors was examined on enrichment of cancer stem cells (CSCs) and tumor growth using in vitro and in vivo models.

Item Type: Article
Subjects: Cancer Biology
Depositing User: Mr. Rameshwar Nema
Date Deposited: 25 Apr 2022 11:03
Last Modified: 25 Apr 2022 11:03
URI: http://nccs.sciencecentral.in/id/eprint/1120

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