Mohan , T. and Mitra , D. and Rao , D.N. (2014) Nasal delivery of PLG microparticle encapsulated defensin peptides adjuvanted gp41 antigen confers strong and long-lasting immunoprotective response against HIV-1. Immunologic Research, 58 (1). pp. 139-153.

Full text not available from this repository. (Request a copy)

Abstract

Defensins display immunostimulatory activities including a chemotactic effect for T lymphocytes/immature dendritic cells and secretion of pro-inflammatory cytokines suggest their role in bridging innate and adaptive immunity. We hypothesized whether defensins with separately emulsified HIV-1 immunogen would elicit peptide-specific systemic and mucosal antibody response in mice. The HIV-1 peptide alone in microsphere showed low peptide-specific antibody response in sera and different washes, while the presence of defensins markedly increased the antibody peak titre both in sera (102,400–409,600) (p < 0.05) and in washes (800–25,600) (p < 0.001). Defensins with HIV-1 peptide were showing 43.0–83.2 % and 38.7–72.3 % in vitro neutralization against laboratory isolates in serum and lavage samples, respectively, higher than HIV-1 peptide alone. Our findings may have implications in the development of new mucosal adjuvant for AIDS vaccination.

Item Type:	Article
Subjects:	Infection and Immunity
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	24 Apr 2015 05:49
Last Modified:	01 Jul 2015 08:28
URI:	http://nccs.sciencecentral.in/id/eprint/114

Actions (login required)

View Item