Giri , S and Meitei , HT and Mishra , A and Lal , G (2022) +Vγ2+ γδ T cells in the presence of anti-CD40L control surgical inflammation and promote skin allograft survival. Journal of Investigative Dermatology, 142 (10). pp. 2706-2714.

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Abstract

γδ T cells represent a small fraction of total T cells in the body and do not use classical polymorphic major histocompatibility complex‒loaded peptides for mounting an immune response. The importance of the effector and regulatory function of γδ T cells in infections, autoimmunity, and tumor models are well characterized. In this study, we investigated the mechanistic role of γδ T cells in costimulatory blockade‒induced transplantation tolerance. We used donor-specific transfusion and anti-CD40L treatment in C57BL/6 mice to induce tolerance to BALB/c skin allografts. We show that depletion of γδ T cells, specifically Vγ2+ γδ T cells, led to the acute rejection of skin allografts despite tolerogen treatment. Tolerogen treatment promoted CD39+Vγ2+ γδ T cells and suppressed IFN-γ‒producing Vγ2+ γδ T cells in the spleen and allografts. Vγ2+ γδ T cells isolated from tolerized mice suppress T helper type 1 cell differentiation. Adoptive transfer of these regulatory Vγ2+ γδ T cells prolonged the survival of allografts in an untreated recipient and Tcrδ‒/‒ mice. Together, our data show that the Vγ2+ subset promotes costimulatory blockade‒induced survival of skin allografts and that tolerogenic Vγ2+ T cells can be used as an adoptive cellular therapy to promote the survival of allografts.

Item Type:	Article
Additional Information:	National Centre for Cell Science, NCCS Complex, SPPU Campus, Ganeshkhind, Pune, MH-411007, India
Subjects:	Infection and Immunity
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	18 Oct 2022 06:34
Last Modified:	18 Oct 2022 06:34
URI:	http://nccs.sciencecentral.in/id/eprint/1164

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