Paul, S. and Singh, A.K. and Shilpi, and Lal , G. (2014) Phenotypic and Functional Plasticity of Gamma–Delta (γδ) T Cells in Inflammation and Tolerance. International Reviews of Immunology, 33. pp. 537-558.

Full text not available from this repository. (Request a copy)

Abstract

Gamma–delta T cells (γδ T cells) are an unique group of lymphocytes and play an important role in bridging the gap between innate and adaptive immune systems under homeostatic condition as well as during infection and inflammation. They are predominantly localized into the mucosal and epithelial sites, but also exist in other peripheral tissues and secondary lymphoid organs. γδ T cells can produce cytokines and chemokines to regulate the migration of other immune cells, can bring about lysis of infected or stressed cells by secreting granzymes, provide help to B cells and induce IgE production, can present antigen to conventional T cells, activate antigen presenting cells (APC) maturation, and are also known to produce growth factors that regulate the stromal cell function. γδ T cells spontaneously produce IFN-γ and IL-17 cytokines compared to delayed differentiation of Th1 and Th17 cells. In this review, we discussed the current knowledge about the mechanism of γδ T cell function including its mode of antigen recognition, and differentiation into various subsets of γδ T cells. We also explored how γδ T cells interact with different types of innate and adaptive immune cells, and how these interactions shape the immune response highlighting the plasticity and role of these cells—protective or pathogenic under inflammatory and tolerogenic conditions.

Item Type:	Article
Subjects:	Infection and Immunity
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	24 Apr 2015 06:54
Last Modified:	01 Jul 2015 09:09
URI:	http://nccs.sciencecentral.in/id/eprint/117

Actions (login required)

View Item