Guhe, V and Anjum, F and Shafie, A and Hassan, MI and Rao, PV and Singh, S (2022) Infection Dynamics of ATG8 in Leishmania: Balancing Autophagy for Therapeutic. Molecules , 27 (10). p. 3142.

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Abstract

In many regions of the world, Leishmaniasis is a cause of substantial mortality and ailment. Due to impediment in available treatment, development of novel and effective treatments is indispensable. Significance of autophagy has been accentuated in infectious disease as well as in Leishmaniasis, and it is having capability to be manifested as a therapeutic target. By evincing autophagy as a novel therapeutic regime, this study emphasized on the critical role of ATG4.1-ATG8 and ATG5-ATG12 complexes in Leishmania species. The objective here was to identify ATG8 as a potential therapeutic target in Leishmania. R71T, P56E, R18P are the significant mutations which shows detrimental effect on ATG8 while Arg276, Arg73, Cys75 of ATG4.1 and Val88, Pro89, Glu116, Asn117, and Gly120 are interacting residues of ATG8. Along with this, we also bring into spotlight an enticing role of Thiabendazole derivatives that interferes with the survival mechanisms by targeting ATG8. Further, the study claims that thiabendazole can be a potential drug candidate to target autophagy process in the infectious disease Leishmaniasis

Item Type:	Article
Additional Information:	1.National Centre for Cell Science, Pune 411007, India (CS) 2.Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia 3.Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India 4.Universiti Malaysia Sabah, Kota Kinabalu 44800, Sabah, Malaysia 5.Abdurrab University, Pekanbaru 28291, Riau, Indonesia 6.Reva University, Yelahanka, Bangalore 560064, India
Subjects:	Bioinformatics and Proteomics
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	18 Oct 2022 11:47
Last Modified:	18 Oct 2022 11:47
URI:	http://nccs.sciencecentral.in/id/eprint/1173

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