Surve, C and Banerjee, A and Anupriya, S and Chakraborty , R and Kumar, D and Butti, R and Gorain, M and Parida, S and Kundu, GC and Shidhaye, S and Patnaik, S (2022) Antiproliferative and apoptotic potential of methotrexate lipid nanoparticle in murine breast cancer model. Nanomedicne, 17 (11). pp. 753-764.

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Abstract

Aim: To evaluate the efficacy of novel methotrexate-loaded nanoparticles (MTX-NPs) in vitro and in vivo in the treatment of breast cancer. Materials & methods: MTX-NPs were tested for cellular uptake, cell viability, cell cycle, cellular wound migration and changes in tumor volume using characterized NPs. Results: The solid lipid NPs (SLNPs) showed strong cellular uptake, increased apoptosis, controlled cytotoxicity at lower IC50 of methotrexate and a sizable reduction in tumor burden. Conclusion: MTX-NP oral formulation can be a promising candidate in breast cancer treatment with improved cellular uptake and in vivo efficacy.

Item Type:	Article
Subjects:	Cancer Biology
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	19 Oct 2022 05:57
Last Modified:	19 Oct 2022 07:19
URI:	http://nccs.sciencecentral.in/id/eprint/1176

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