afarzadeh, A and Nemati, M and Aminizadeh, N and Bodhale, N and Sarkar, A and Jafarzadeh, S and Sharifi , I and Saha, B (2022) Bi-directional Cytokine microRNA control: a novel immunoregulatory framework in Leishmaniasis. PLoS Pathogens, 18 (8). e1010696.

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Abstract

As effector innate immune cells and as a host to the protozoan parasite Leishmania, macrophages play a dual role in antileishmanial immunoregulation. The 2 key players in this immunoregulation are the macrophage-expressed microRNAs (miRNAs) and the macrophage-secreted cytokines. miRNAs, as small noncoding RNAs, play vital roles in macrophage functions including cytokines and chemokines production. In the reverse direction, Leishmania-regulated cytokines alter miRNAs expression to regulate the antileishmanial functions of macrophages. The miRNA patterns vary with the time and stage of infection. The cytokine-regulated macrophage miRNAs not only help parasite elimination or persistence but also regulate cytokine production from macrophages. Based on these observations, we propose a novel immunoregulatory framework as a scientific rationale for antileishmanial therapy.

Item Type:	Article
Subjects:	Infection and Immunity
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	20 Oct 2022 07:59
Last Modified:	20 Oct 2022 07:59
URI:	http://nccs.sciencecentral.in/id/eprint/1196

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