Mondal, A and Barik , GK and Sarkar, S and Mondal , D and Ahmad, M and Vijayakanth, T and Mondal, J and Santra, MK and Talukdar, P (2022) Nontoxic Artificial Chloride Channel Formation in Epithelial Cells by Isophthalic Acid-Based Small Molecules. Chemistry : A European Journal. e202202887.

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Abstract

Artificial channels capable of facilitating the transport of Cl− ions across cell membranes while being nontoxic to the cells are rare. Such synthetic ion channels can mimic the functions of membrane transport proteins and, therefore, have the potential to treat channelopathies by replacing defective ion channels. Here we report isophthalic acid-based structurally simple molecules 1 a and 2 a, which self-assemble to render supramolecular nanochannels that allow selective transport of Cl− ions. As evident from the single-crystal X-ray diffraction analysis, the self-assembly is governed by intermolecular hydrogen bonding and π-π stacking interactions. The MD simulation studies for both 1 a and 2 a confirmed the formation of stable Cl− channel assembly in the lipid membrane and Cl− transport through them. The MQAE assay showed the efficacy of the compounds in delivering Cl− ions into cells, and the MTT assays proved that the compounds are nontoxic to cells even at a concentration of 100 μM.

Item Type:	Article
Additional Information:	1.Indian Institute of Science Education and Research Pune, INDIA. 2.Tata Institute of Fundamental Research Hyderabad, INDIA. 3.Tel Aviv University, The Shmunis School of Biomedicine and Cancer Research, ISRAEL. 4.National Centre For Cell Science, Biotechnology, INDIA.
Subjects:	Cancer Biology
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	11 Jan 2023 11:06
Last Modified:	11 Jan 2023 11:06
URI:	http://nccs.sciencecentral.in/id/eprint/1235

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