Gulhane, P and Singh , S Unraveling the Post-Translational Modifications and therapeutical approach in NSCLC pathogenesis. Translational Oncology. 33 (2023) 101673. Translational Oncology.

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Abstract

Non-Small Cell Lung Cancer (NSCLC) is the most prevalent kind of lung cancer with around 85% of total lung cancer cases. Despite vast therapies being available, the survival rate is low (5 year survival rate is 15%) making it essential to comprehend the mechanism for NSCLC cell survival and progression. The plethora of evidences suggests that the Post Translational Modification (PTM) such as phosphorylation, methylation, acetylation, glycosylation, ubiquitination and SUMOylation are involved in various types of cancer progression and metastasis including NSCLC. Indeed, an in-depth understanding of PTM associated with NSCLC biology will provide novel therapeutic targets and insight into the current sophisticated therapeutic paradigm. Herein, we reviewed the key PTMs, epigenetic modulation, PTMs crosstalk along with proteogenomics to analyze PTMs in NSCLC and also, highlighted how epi‑miRNA, miRNA and PTM inhibitors are key modulators and serve as promising therapeutics.

Item Type:	Article
Additional Information:	National Centre for Cell Science, NCCS Complex, Ganeshkhind, SPPU Campus, Pune 411007, India
Subjects:	Cancer Biology
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	18 Apr 2023 11:51
Last Modified:	18 Apr 2023 11:51
URI:	http://nccs.sciencecentral.in/id/eprint/1258

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