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Puri , D and Shalmali Bivalkar-Mehla, S and Subramanyam , D (2022) Autophagy in embryonic stem cells and neural stem cells. In: Autophagy in stem cell maintenance and differentiation. Stem Cell Biology and Regenerative Medicine book series (STEMCELL,volume 73) . Springer-Nature, pp. 59-83.

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Autophagy is a conserved cytoprotective catabolic pathway that plays a crucial role in cellular turnover and homeostasis in eukaryotic cells. A large body of work has implicated autophagy in normal development and differentiation of mammalian cells. In particular, precise regulation of autophagy is important for the maintenance of stemness and differentiation of embryonic stem cells. Extensive reports also indicate a critical role of autophagy in neural stem cells and during embryonic and adult neurogenesis. One of the critical stages of autophagy regulation occurs at the level of expression of autophagy genes. Transcription factors and chromatin modulators govern the accessibility of autophagy genes to the transcription machinery and regulate their expression. Understanding autophagy regulation in stem cells becomes critical as aberrant autophagy leads to numerous degenerative and neuropsychological diseases. This chapter aims to provide an overview of autophagy in embryonic stem cells and neural stem cells with a focus on regulation of autophagy genes in these cellular states.

Item Type: Book Section
Subjects: Cell Biology
Stem Cell Biology
Depositing User: Mr. Rameshwar Nema
Date Deposited: 04 Aug 2023 08:00
Last Modified: 07 Aug 2023 09:53
URI: http://nccs.sciencecentral.in/id/eprint/1273

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