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Samanta, S and Mahata, R and Santra , MK (2022) The Cross-Talk between Epigenetic Gene Regulation and Signaling Pathways Regulates Cancer Pathogenesis. In: Metabolism and Epigenetic Regulation: Implications in Cancer. Subcellular Biochemistry book series (SCBI,volume 100). (100). Springer, pp. 427-472.

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Cancer begins due to uncontrolled cell division. Cancer cells are insensitive to the signals that control normal cell proliferation. This uncontrolled cell division is due to the accumulation of abnormalities in different factors associated with the cell division, including different cyclins, cell cycle checkpoint inhibitors, and cellular signaling. Cellular signaling pathways are aberrantly activated in cancer mainly due to epigenetic regulation and post-translational regulation. In this chapter, the role of epigenetic regulation in aberrant activation of PI3K/AKT, Ras, Wnt, Hedgehog, Notch, JAK/STAT, and mTOR signaling pathways in cancer progression is discussed. The role of epigenetic regulators in controlling the upstream regulatory proteins and downstream effector proteins responsible for abnormal cellular signaling-mediated cancer progression is covered in this chapter. Similarly, the role of signaling pathways in controlling epigenetic gene regulation-mediated cancer progression is also discussed. We have tried to ascertain the current status of potential epigenetic drugs targeting several epigenetic regulators to prevent different cancers.

Item Type: Book Section
Subjects: Cancer Biology
Depositing User: Mr. Rameshwar Nema
Date Deposited: 08 Aug 2023 09:41
Last Modified: 08 Aug 2023 09:41
URI: http://nccs.sciencecentral.in/id/eprint/1284

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