Banerjee , P and Kapse , P and Siddique, S and Kundu, M and Choudhari, J and Mohanty, V and Malhotra, D and Gosavi, SW and Gacche, RN and Kundu, GC (2023) Therapeutic implications of cancer stem cells in prostate cancer. Cancer Biology & Medicine.

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Abstract

Prostate cancer, one of the most frequently occurring cancers in men, is a heterogeneous disease involving multiple cell types within tumors. This tumor heterogeneity at least partly results from genomic instability leading to sub-clonal cellular differentiation. The differentiated cell populations originate from a small subset of cells with tumor-initiating and stem-like properties. These cells, termed prostate cancer stem cells (PCSCs), play crucial roles in disease progression, drug resistance, and relapse. This review discusses the origin, hierarchy, and plasticity of PCSCs; methods for isolation and enrichment of PCSCs; and various cellular and metabolic signaling pathways involved in PCSC induction and maintenance, as well as therapeutic targeting.

Item Type:	Article
Subjects:	Cancer Biology
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	08 Aug 2023 11:16
Last Modified:	08 Aug 2023 11:16
URI:	http://nccs.sciencecentral.in/id/eprint/1289

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