Tamahane, V and Bhanushali, S and Shah, N and Gupta, A and Khadilkar, V and Gondhalekar, K and Khadilkar, A and Shouche, YS (2023) comparative study of the gut microbiome in Indian children with type 1 diabetes and healthy controls. Journal of Diabetes. ISSN Wiely

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Abstract

Introduction Type 1 diabetes mellitus (T1DM) occurs in genetically susceptible individuals due to certain environmental triggers causing destruction of insulin secreting beta cells. One of the environmental triggers studied recently in the pathogenesis and progression of T1DM is the role of gut microbiome. Objectives (1) To compare the gut microbiome profile of T1DM children with healthy age, gender, and body mass index (BMI) matched controls. (2) To assess the relationship of abundance of genera with glycemic control in children with T1DM. Methods Cross-sectional, case–control study. Sixty-eight children with T1DM and 61 age-, gender-, and BMI-matched healthy controls were enrolled. QIAamp Fast DNA Stool Mini kit protocol and reagents were used for DNA isolation and Miseq sequencing platform for targeted gene sequencing.

Item Type:	Article
Subjects:	Diabetes
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	09 Aug 2023 09:48
Last Modified:	09 Aug 2023 09:48
URI:	http://nccs.sciencecentral.in/id/eprint/1292

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