Mol., M. and Singh , S. (2014) In silico Approaches for Dealing With Gene Regulatory Networks to Understand Molecular Mechanisms of Immunity in Infectious Disease. In: Genomics and Drug Discovery. Benthum Science, pp. 1-20. (In Press)

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Abstract

Jacob and Monad laid the concept of mechanism of gene regulation by studying the lac operon in E coli in 1961and since then several traditional approaches have been applied to analyze this phenomenon considering natural systems as a model or by analyzing abstract models to obtain general results. Post-human genome project and advances in high-throughput measuring techniques has resulted in volumes of data, identifying the gene and protein components making up an organism. In an organism, these components interact to form a complex network to achieve their biological function. Qualitative and quantitative understanding of these networks in an individual organism and in combination (host and parasite) would help uncover novel biological pathways and interactions between cells in an infectious disease state. This is an important step in finding disease markers and deciding the mode of treatment, or in the near future towards building synthetic components to intervene the prognosis of a disease.

Item Type:	Book Section
Subjects:	Bioinformatics and Proteomics
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	27 May 2015 06:45
Last Modified:	02 Jul 2015 06:22
URI:	http://nccs.sciencecentral.in/id/eprint/179

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