Hardikar , A.A. and Satoor , S.N. and Karandikar, M.S. and Joglekar , M.V. and Puranik , A.S. and Wong, W. and Kumar , S. and Limaye , A. and Bhat , D.S. and Januszewski , A.S. and Umrani , M.R. and Ranjan , A.K. and Apte , K. and Yajnik , P. and Bhonde , R.R. and Galande , S. (2015) Multigenerational Undernutrition Increases Susceptibility to Obesity and Diabetes that Is Not Reversed after Dietary Recuperation. Cell Metab. 2015 Aug 4;22(2):312-9., 22 (2). pp. 312-319.

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Abstract

People in developing countries have faced multigenerational undernutrition and are currently undergoing major lifestyle changes, contributing to an epidemic of metabolic diseases, though the underlying mechanisms remain unclear. Using a Wistar rat model of undernutrition over 50 generations, we show that Undernourished rats exhibit low birth-weight, high visceral adiposity (DXA/MRI), and insulin resistance (hyperinsulinemic-euglycemic clamps), compared to age-/gender-matched control rats. Undernourished rats also have higher circulating insulin, homocysteine, endotoxin and leptin levels, lower adiponectin, vitamin B12 and folate levels, and an 8-fold increased susceptibility to Streptozotocin-induced diabetes compared to control rats. Importantly, these metabolic abnormalities are not reversed after two generations of unrestricted access to commercial chow (nutrient recuperation). Altered epigenetic signatures in insulin-2 gene promoter region of Undernourished rats are not reversed by nutrient recuperation, and may contribute to the persistent detrimental metabolic profiles in similar multigenerational undernourished human populations.

Item Type:	Article
Subjects:	Cell Biology
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	01 Sep 2015 09:58
Last Modified:	01 Sep 2015 09:58
URI:	http://nccs.sciencecentral.in/id/eprint/199

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