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Kumar, A. and Deore , S and Kumar, S. and Bankar , T. and Lotke , A. and Parab , P. and Krishnasastry , M.V. (2015) Kix domain specific Immunoglobulin A can protect from adverse lung and cerebral pathology induced by Plasmodium berghei ANKA. Biochemical and Biophysical Research Communications, 464 (3). pp. 943-948. ISSN Volume 464, Issue 3, 28 August 2015, Pages 943–948

50.. Dr. M.V. Krishnasastry (BBRC) paid open access.pdf

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Plasmodium specific IgA has been detected in serum and breast milk among the endemic population but the role it can play in vivo is not clear. In this report, we demonstrate the utility of Malaria specific IgA, elicited by peptide sequences (referred as Mpep3 and Mpep4) of region VI of EBA-175 (PfrVI). Immunization of mice with KLH tagged or untagged peptides of Mpep3, Mpep4 or with PfrVI have resulted in specific IgA response that inhibits the in vitro invasion of Plasmodium falciparum merozoites. Mice having the IgA specific to Mpep4 have exhibited higher tolerance to Plasmodium berghei ANKA parasitemia, exhibited several fold lesser sequestration of infected RBC, lesser damage to microvasculature with no signs of perivascular haemorrhage and lesser lung inflammation in comparison to unimmunized mice. In addition, the immunized mice have B-cell population that secrete the IgA specific to PfrVI. These results suggest that the IgA specific to these malarial antigens can confer significant advantage to hosts and it may also reduce the severity of malaria infection.

Item Type: Article
Additional Information: This is Open Access article for full text click above weblink
Subjects: Cell Biology
Depositing User: Mr. Rameshwar Nema
Date Deposited: 01 Sep 2015 10:16
Last Modified: 19 Feb 2016 08:17
URI: http://nccs.sciencecentral.in/id/eprint/201

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