Paul, S and Lal , G. (2016) Regulatory and effector functions of gamma-delta (γδ) T cells and their therapeutic potential in adoptive cellular therapy for cancer. International Journal of Cancer .

Text 51.Dr. Lal G. (Int. Jr. of Cancer ) author copy .pdf - Accepted Version Restricted to Registered users only until May 2017. Download (782Kb) | Request a copy

Abstract

γδ T cells are an important innate immune component of the tumor microenvironment and are known to affect the immune response in a wide variety of tumors. Unlike αβ T cells, γδ T cells are capable of spontaneous secretion of IL-17A and IFN-γ without undergoing clonal expansion. Although γδ T cells do not require self-MHC restricted priming, they can distinguish 'foreign' or transformed cells from healthy self-cells by using activating and inhibitory killer Ig-like receptors. γδ T cells were used in several clinical trials to treat cancer patient due to their MHC-unrestricted cytotoxicity, ability to distinguish transformed cells from normal cells, the capacity to secrete inflammatory cytokines and also their ability to enhance the generation of antigen-specific CD8+ and CD4+ T cell response. In this review, we discuss the effector and regulatory function of γδ T cells in the tumor microenvironment with special emphasis on the potential for their use in adoptive cellular immunotherapy. This article is protected by copyright. All rights reserved.

Item Type:	Article
Subjects:	Infection and Immunity
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	24 May 2016 08:40
Last Modified:	24 May 2016 08:42
URI:	http://nccs.sciencecentral.in/id/eprint/236

Actions (login required)

View Item