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Full text not available from this repository. (Request a copy)Abstract
We describe the design, synthesis and SAR profiling of a series of novel combretastatin-nocodazole conjugates as potential anticancer agents. The thiophene ring in the nocodazole moiety was replaced by a substituted phenyl ring from the combretastatin moiety to design novel hybrid analogues. The hydroxyl group at the ortho position in compounds 2, 3 and 4 was used as the conformationally locking tool by anticipated six-membered hydrogen bonding. The bioactivity profiles of all compounds as tubulin polymerization inhibitors and as antiproliferative agents against the A-549 human lung cancer cell line were investigated Compounds 1 and 4 showed μM IC50 values in both assays.
Item Type: | Article |
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Additional Information: | This is online free article for full text click above weblink |
Subjects: | Infection and Immunity |
Depositing User: | Mr. Rameshwar Nema |
Date Deposited: | 27 May 2016 04:56 |
Last Modified: | 27 May 2016 04:56 |
URI: | http://nccs.sciencecentral.in/id/eprint/251 |
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