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Butti, R. and Ghosh, P. and Kumar , V.S. and Totakura, K.V.S. and Radharani , N. and Venkata, N. and Nimma, R. and Kundu , G.C. (2015) Role of Osteopontin in Tumor Microenvironment: A New Paradigm in Cancer Therapy. In: Multi-Targeted Approach to Treatment of Cancer,. Springer International Publishing Switzerland, pp. 113-125. ISBN 978-3-319-12252-6

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Abstract Cancer is a complex, multifactorial disease, emerged due to dysregulation of one or more cellular signaling cascades by somatic or germ line mutations. However, tumor progression vastly depends on context-dependent interaction between cancer cells and its surrounding microenvironment. Tumor microenvironment plays multifaceted role in tumor progression by providing not only a structural framework but also proliferative, metastatic, and angiogenic signals. It is well established that array of growth factors, cytokines, and chemokines acts at the interface of tumor and stromal cells. Osteopontin (OPN), a chemokine-like protein, is overexpressed in various tumor tissues and cell lines. It has immense potential to regulate various hallmarks of cancer. Presumably, targeting the communication between the tumor cells and surrounding microenvironment using specific antibodies, small molecule inhibitors, and chemotherapeutic agents by exploiting OPN as a central molecule are novel therapeutic strategies for management of cancer.

Item Type: Book Section
Subjects: Cancer Biology
Depositing User: Mr. Rameshwar Nema
Date Deposited: 31 May 2016 04:49
Last Modified: 31 May 2016 04:49
URI: http://nccs.sciencecentral.in/id/eprint/284

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