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Saha , B. (2015) Antigens. In: UNSPECIFIED Wiely, DOI: 10.1002/9780470015902.a0000499.pub3.

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Any molecule ranging from simple chemical compounds to complex macromolecules, which are capable of being recognised by one or more constituents of the innate and adaptive immune system, is called an ‘antigen’. In the innate immune system, antigens are the pathogen-associated molecular patterns recognised by the pattern recognition receptors expressed on macrophages, dendritic cells and NK cells. NK cells express an array of additional sets of receptors that recognise unconventional antigens. In the adaptive immune system, the B-lymphocyte-expressed immunoglobulin and T-lymphocyte-expressed T cell receptor recognise either specific conformation on the antigen or the amino acid sequence in the peptide, respectively. The antigens, which induce tolerogenic response or an allergic response, are called tolerogens or allergens, respectively. However, all antigens do not necessarily elicit antigen-specific immune responses; those eliciting an immune response are termed immunogens. So, antigenicity of a molecule refers to its capacity to be recognised by the immune receptors, whereas immunogenicity is its ability to induce an immune response. Thus, all immunogens are antigens but all antigens are not

Item Type: Book Section
Subjects: Infection and Immunity
Depositing User: Mr. Rameshwar Nema
Date Deposited: 31 May 2016 05:50
Last Modified: 31 May 2016 09:01
URI: http://nccs.sciencecentral.in/id/eprint/288

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