Dhenge, , A.C. and Kale, V.P. and Limaye, L. (2015) Enhancement of hematopoiesis and thrombopoiesis by pharmacological compounds valproic acid and all- trans retinoic acid. Journal of Pharmacy Sci. Tech. Mgmt, 1 (2). ISSN Volume 1, Issue 2, July 2015

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Abstract

The two processes , Megakaryopoiesis and Thrombopoiesis are important from a clinical perspective. Abnormalities in these processes lead to conditions such as thrombocytopenia, for which no specific and accurate treatments are available.In umbilical cord blood transplantation the megakaryocyte progenitor population is less and its engraftment is delayed, thus there is a need of ex-vivo expansion of these progenitors for better platelet recovery .Methods of in vitro generation of megakaryocytes (MKs) and platelets serve as a good tool to understand the process of platelet biogenesis and also to overcome hurdles in platelet transfusion. Pharmacological compounds like Thrombopoietin (TPO) mimetics (eltrombopag), HDAC inhibitors (Valproic acid, VPA) and vitamin A derivative (all-trans retinoic acid, ATRA) are being used to enhance the production of platelets. This kind of study will contribute in understanding the basic cellular and molecular events taking place during megakaryopoiesis and thrombopoiesis and will also give us insight on clinical treatment of prolonged thrombocytopenia during stem cell transplant and other platelet disorders. In this review, we will mainly discuss about the importance of different sources, strategies and use of pharmacological compounds like VPA and ATRA in MK and platelet generation.

Item Type:	Article
Additional Information:	This is Open Access article
Subjects:	Stem Cell Biology
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	13 Dec 2016 09:18
Last Modified:	22 Feb 2021 11:56
URI:	http://nccs.sciencecentral.in/id/eprint/309

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