Gorai, S. and Bagdi,, P.R. and Borah,, R. and Paul, D. and Santra, M.K. and Khan, A.T. and Manna, D. (2015) Insights into the inhibitory mechanism of triazole-based small molecules on phosphatidylinositol-4,5-bisphosphate binding pleckstrin homology domain. Biochemistry and Biophysics Reports, 2. pp. 75-86.

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Abstract

Phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] is an important regulator of several cellular processes and a precursor for other second messengers which are involved in cell signaling pathways. Signaling proteins preferably interact with PI(4,5)P2 through its pleckstrin homology (PH) domain. Efforts are underway to design small molecule-based antagonist, which can specifically inhibit the PI(4,5)P2/PH-domain interaction to establish an alternate strategy for the development of drug(s) for phosphoinositide signaling pathways.

Item Type:	Article
Subjects:	Cancer Biology
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	14 Dec 2016 04:44
Last Modified:	22 Feb 2021 12:04
URI:	http://nccs.sciencecentral.in/id/eprint/316

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