Naiyer, M.M. and Saha, S. and Hemke , V. and Roy , S. and Singh , S. and Musti , K.V. and Saha , B. (2013) Identification and characterization of a human IL-10 receptor antagonist. Human Immunology, 74. pp. 28-31.

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Abstract

Interleukin-10 (IL-10) is an anti-inflammatory cytokine that works through IL-10 receptor alpha subunitand suppresses immune responses in many infectious diseases such as leishmaniasis as well as in cancer. Therefore, in order to restore the host-protective immune responses in such diseases, an antagonist to this cytokine is a pressing need. Herein, using phage peptide library display, we have identified a dodecameric peptide that functions as an antagonist to human IL-10 receptor in an IL-10-induced STAT3 phosphorylation assay. The peptide antagonist’s ability to restore anti-leishmanial function in CD40-activated macrophages was also tested. We observed that the peptide reduced IL-10-induced STAT-3 phosphorylation and enhanced CD40-activated leishmanial functions in macrophages. � 2012 American Society for Histocompatibility and Immunogenetics.

Item Type:	Article
Subjects:	Infection and Immunity
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	10 Apr 2015 04:38
Last Modified:	02 Jul 2015 10:17
URI:	http://nccs.sciencecentral.in/id/eprint/34

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