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Bapat , S.A (2016) Cancer Stem Cells: Perspectives beyond immunophenotypes and markers, In: Regenerative Medicine,. In: Regenerative Medicine - from Protocol to Patient. Cancer Stem Cells: Perspectives Beyond Immunophenotypes and Markers . Springer International Publishing, pp. 273-293. ISBN 978-3-319-27608-3

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Decades of cancer research have failed to resolve therapeutic refractoriness and tumor dormancy that leads to disease recurrence. This presents formidable obstacles in achieving total remission for patients in several cancers. It is however realized that residual tumor regenerative potential resides in a rare population of cells with properties of self-renewal that permit them to remain quiescent yet contribute to recurrent disease. These cells are referred to as either Cancer stem cells (CSCs) or Tumor Initiating Cells (TICs), and their isolation, identification and extensive characterization followed through the establishment of several phenotypic and functional in vitro and in vivo assays. Notably, similarities with normal tissue stem cells have emphasized the need of developing new approaches for their specific targeting as opposed to current chemo- or radio-therapy. Thereby considerable interest and research has culminated in elucidating the behavior of CSCs vis-à-vis their deviations from normal stem cell performance, which might provide therapeutic novel cues. However, their identification, characterization and understanding of the cellular contexts in which they can be formidable yet have not been truly achieved beyond the development of convenient tools. This chapter outlines the present challenges in the field of CSC biology.

Item Type: Book Section
Subjects: Stem Cell Biology
Depositing User: Mr. Rameshwar Nema
Date Deposited: 15 Dec 2016 08:06
Last Modified: 15 Dec 2016 08:06
URI: http://nccs.sciencecentral.in/id/eprint/341

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