Chatterjee , S and Panda , A.C and Sunil , K and Sreejith , B and Charu Ritvika , R.K. and Seshadri , V. and Pal , J.K. (2013) Vimentin is a component of a complex that binds to the 50-UTR of human heme-regulated eIF2a kinase mRNA and regulates its translation. FEBSLetters, 587. pp. 474-480.

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Abstract

The human heme-regulated eIF2a kinase, also called the human heme-regulated inhibitor (hHRI) is significantly up-regulated particularly at the level of translation during stress. In this report we show that during lead-stress, the regulation of hHRI mRNA translation is mediated through its 50- untranslated region (UTR) that interacts with specific trans-acting factors. Further, vimentin has been identified as one of the trans-acting factors that contribute to this regulation. � 2013 Federation of European Biochemical Societies.

Item Type:	Article
Subjects:	Cancer Biology
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	13 Apr 2015 05:44
Last Modified:	02 Jul 2015 11:22
URI:	http://nccs.sciencecentral.in/id/eprint/47

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