Ginotra , Y. and Ramteke , S. and Rapole , S. and Kulkarni , P (2012) Mass Spectral Studies Reveal the Structure of Aβ1−16−Cu2+ Complex Resembling ATCUN Motif. Inorganic Chemistry, 51 (9). pp. 7960-7962.

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Abstract

In Alzheimer’s disease, copper binds to amyloid beta (Aβ) peptide and generates oxidative stress. The coordination of histidine (His) residues to Cu2+ is still uncertain. We studied Cu2+ binding to Aβ1−16 peptide using the diethyl pyrocarbonate (DEPC) assay and mass spectrometry. Our results show that only one His is involved in Cu2+ coordination, which is identified as His6 using mass spectral studies. Novel nickel displacement studies have further supported the proposal that the Cu2+ binding site of Aβ1−16 peptide resembles the ATCUN motif of human serum albumin.

Item Type:	Article
Subjects:	Cancer Biology
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	01 Apr 2015 10:12
Last Modified:	02 Jul 2015 08:54
URI:	http://nccs.sciencecentral.in/id/eprint/5

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