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Shirolkar, G.D. and Pasic, S. and Gogoi-Tiwari, J. and Bhat , M.K. and Olynyk, J.K. and Dharmarajan, A. and Tirnitz-Parker, JEE (2018) Wnt/β-Catenin signalling during liver metabolism, chronic liver disease and hepatocarcinogenesis. Journal of Renal and Hepatic Disorders,, 1 (2).

66. Dr. Bhat MK.(J Renal Hepatic Disor.) open access.pdf

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Chronic liver diseases (CLDs) are increasing in prevalence and their end-stage complications, namely, cirrhosis, liver failure and hepatocellular carcinoma represent major global challenges. The most common initiators of progressive CLD are viral hepatitis and long-term alcohol abuse as well as steatosis and steatohepatitis. Irrespective of the underlying aetiology, a common feature of CLD is the formation of hepatic ductular reactions, involving the proliferation of liver progenitor cells (LPCs) and their signalling to fibrosis-driving hepatic stellate cells. The Wnt/β-catenin pathway has been found to regulate development, stemness and differentiation, and alterations in its activity have been associated with tumour development. Recent data highlight the role of Wnt/β-catenin signalling in hepatic metabolism, steatosis and cancer, and suggest targeting of this pathway as a promising molecular strategy to potentially inhibit CLD progression and hepatocarcinogenesis.

Item Type: Article
Subjects: Cell Biology
Depositing User: Mr. Rameshwar Nema
Date Deposited: 17 Dec 2018 06:07
Last Modified: 19 Feb 2021 06:42
URI: http://nccs.sciencecentral.in/id/eprint/560

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