Sivakrishna B, B. and Islam , S. and Panda , A. and Saranya, M. and Santra , M.K. and Pal, S. (2018) Synthesis and Anticancer Properties of Novel Truncated Carbocyclic Nucleoside Analogues. Anti-Cancer Agents in Medicinal Chemistry , 18 (10).

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Abstract

Series of novel truncated carbocyclic nucleoside analogues have been synthesized from the versatile starting material D-ribose and their anticancer activities have been evaluated. The nucleoside analogues induced cytotoxicity in breast and ovarian cancer cell lines. These compounds are less cytotoxic to normal kidney cell line (HEK 293) as compared to the cancer cells. Among the synthesized compounds, 1b and 1d showed the better cytotoxic effect with IC50 44 and 54 μM, in MCF7 cells, respectively. These compounds inactivate the important signaling kinases AKT and mTOR and thereby induce autophagy. Collectively our observation suggests that compound 1b and 1d inhibit the cancer cell proliferation through induction of autophagy mode of cell death.

Item Type:	Article
Subjects:	Cell Biology
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	17 Dec 2018 09:35
Last Modified:	17 Dec 2018 09:35
URI:	http://nccs.sciencecentral.in/id/eprint/562

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