Mistri, S. and Patra, A. and Santra, M.K. and Paul,, D and Zangrando, E. and Puschmann, H. and Manna, S.C. (2018) DNA/Protein Binding, Molecular Docking and Cytotoxicity Studies of Piperazinyl-Moiety-Based Copper(II) Complexes. Chemistry Select , 31 (3). pp. 9102-9112.

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Abstract

Copper(II) complexes {[Cu(HL)(ClO4)(H2O)](ClO4)⋅3H2O} (1), {[Cu(HL)(m‐phth)]⋅5H2O} (2) and {[Cu(HL)(NCS)]2(ClO4)2⋅2H2O} (3) (HL=2‐{[2‐(1‐piperazinyl)ethylimino]methyl}phenol; m‐phth=1,3‐benzenedicarboxylate] have been synthesized and characterized by structural determination and spectroscopic studies. The mononuclear square pyramidal complex 1 resulted from the reaction of HL with copper perchlorate hexahydrate. Then mononuclear square planar complex 2 and dinuclear thiocyanato bridged complex 3 were obtained by reacting 1 with disodium 1,3‐benzenedicarboxylate (Na2(m‐phth)) and potassium thiocyanate, respectively. The interactions of 1–3 with CT‐DNA / serum albumins were investigated by UV‐visible absorption and fluorescence spectroscopy. The intrinsic binding constants of 1, 2 and 3 with CT‐DNA were calculated as 1.44 (±0.13) × 105, 4.86 (±0.11) × 105 and 4.51 (±0.16) × 105 L mol−1, respectively. Study of the interactions of 1–3 with human serum albumin (HSA) / bovine serum albumin (BSA) showed that all the complexes could quench intrinsic fluorescence of HSA and BSA through a static quenching process. Molecular docking technique was utilised to confirm the mode of interaction of complexes with CT‐DNA / serum albumin. Anticancer activities of the complexes have been tested using human breast cancer cell lines MCF7 and MBA‐MB‐231. Among the complexes studied 3 shows the higher cytotoxic activity and growth inhibition of cancer cells via induction of apoptotic cell death.

Item Type:	Article
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	13 Feb 2020 06:04
Last Modified:	13 Feb 2020 06:04
URI:	http://nccs.sciencecentral.in/id/eprint/627

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