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Bapat, S.A. (2018) Tumor-Initiating Cells in Ovarian Cancer. In: Tumor-Initiating Cells in Ovarian Cancer. Book Chapter-Springer, pp. 61-71.

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Despite advances in clinical oncology, ovarian cancer remains a leading cause of cancer-related deaths in women. Research over the last decade suggests that the aggressive nature of this disease may be attributed to cancer stem cells (CSCs), which represent a very small fraction within tumors with highly regenerative capabilities that achieves tumor growth, invasion, and metastases. These features not only indicate similarities with normal stem cells; moreover CSCs also generate cellular heterogeneity that is now recognized to be a defining characteristic of tumors. Despite this emerging knowledge, identification of ovarian CSCs has been a major challenge due to poor understanding of the niches that lead to their enrichment and lack of complete correlation between surface marker expression and functionality. Herein, I review the current literature in the field with reference to different strategies employed for CSC isolation within the maze of tumor heterogeneity. This suggests an imperative redefinition of CSCs as tumor-initiating cells, which may be more pertinent on the background of their capabilities of regeneration, reversible quiescence, and overcoming microenvironmental stress.

Item Type: Book Section
Depositing User: Mr. Rameshwar Nema
Date Deposited: 18 Feb 2020 06:13
Last Modified: 18 Feb 2020 06:13
URI: http://nccs.sciencecentral.in/id/eprint/674

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