Kalra, R.S. and Bapat, S.A. (2019) Proteomics to Predict Loss of RXR-γ During Progression of Epithelial Ovarian Cancer. In: Retinoid and Rexinoid Signaling.Methods in Molecular Biology book series. Springer , pp. 1-14.

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Abstract

Retinoid and rexinoid receptors are known to regulate key processes during development, differentiation, and cell death in vertebrates. However, their contributions to progression of malignant disease remain largely elusive although it is realized that transformed cancer cells, which essentially evade apoptosis, may display altered molecular expressions or functions associated with retinoid signaling. Here, using a progression model of ovarian cancer, we describe a proteomics-based approach including experimental procedures toward identification and validation of altered protein profiles during transformation. Effectively, this specifies loss of RXR-γ during progression of epithelial ovarian cancer.

Item Type:	Book Section
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	21 Feb 2020 06:26
Last Modified:	21 Feb 2020 06:46
URI:	http://nccs.sciencecentral.in/id/eprint/738

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