Arbade, G.K. and Kumar, V. and Tripathi, V. and Menon, A. and Bose, S and Patro, T.U. (2019) Emblica officinalis loaded poly(ε-caprolactone) electrospun nanofiber scaffold as potential antibacterial and anticancer deployable patch. New Journal of Chemistry, 43 (19).

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Abstract

Biological functions of nanofiber scaffold can be engineered by incorporation of plant extracts into it. In the present study, Emblica officinalis (EO) (Indian Gooseberry known as amla loaded poly(ε-caprolactone) (PCL) nanofibers were prepared by electrospinning technique. The aim is to prepare nanofiber scaffolds with antibacterial and anti-cancerous properties. The scaffolds were characterized by SEM, XRD, small-angle x-ray scattering, FTIR, streaming potential, DSC, water contact angle and tensile test. With incorporation of EO, the nanofiber surface became rougher and showed a ‘braid-like’ morphology. This is in stark contrast to the pristine PCL nanofibers, which showed a smooth fiber surface. The average fiber diameter increased and the water contact angle of nanofiber scaffolds decreased with increase in EO content in PCL. The crystalline structure of PCL was not affected; however, the crystallization temperature increased significantly and the melting temperature increased marginally with the addition of EO. The PCL scaffold showed negatively charged surface and the -potential increased with increase in EO content due to the presence of various functional groups. The antibacterial studies revealed that PCL-EO nanofiber scaffolds showed efficient antibacterial properties against both gram positive and gram negative bacterial strains and the zone of inhibition increased with EO content. The cellular behavior of MCF-7 cells, studied using MTT assay, fluorescent staining and SEM indicates that the cell proliferation was significantly inhibited by incorporation of EO in the scaffolds.

Item Type:	Article
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	21 Feb 2020 09:13
Last Modified:	21 Feb 2020 09:13
URI:	http://nccs.sciencecentral.in/id/eprint/746

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