Panda , J.J. and Kaul , A. and Kumar , S. and Alam , S. and Mishra , A.K. and Kundu , G.C. and Chauhan , V.S. (2013) Modified dipeptide-based nanoparticles: vehicles for targeted tumor drug delivery. Nanomedicine , 8 (12). pp. 1927-1942.

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Abstract

Different nanoparticles have been investigated to deliver chemotherapeutic agents, but complex synthesis procedures and biocompatibility issues raise concerns in developing them for safe human usage. The aim of this work is to develop �,�-dehydrophenylalanine-containing, self-assembled, amphipathic dipeptide nanoparticles for tumor-targeted drug delivery and therapy. Materials & methods: Solution-phase peptide synthesis was used to synthesize dipeptides. Nanoparticles were prepared by molecular self-assembly. A tumor distribution study was carried out using a radiolabeling method. Tumor regression studies were carried out in murine ascitic tumors in BALB/c mice and breast tumor xenografts in nonobese diabetic/severe combined immuno deficiency mice. Results: Arg–�,�-dehydrophenylalanine formed self-assembled nanoparticles that could be easily derivatized with folic acid. Folic acid-derivatized nanoparticles showed enhanced cellular uptake and, when loaded with doxorubicin, showed enhanced tumor regression compared with underivatized nanoparticles or native drug, without any adverse side effects, both in vitro and in vivo.

Item Type:	Article
Subjects:	Cancer Biology
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	13 Apr 2015 10:58
Last Modified:	03 Jul 2015 06:40
URI:	http://nccs.sciencecentral.in/id/eprint/75

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