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Chakraborty , S. and Adhikary , A. and Mazumdar , M. and Mukherjee , S. and Bhattacharjee , P. and Guha , D. and Choudhuri , T. and Chattopadhyay , S. and Sa , G. and Sen , A. and Das , T. (2014) Capsaicin-Induced Activation of p53-SMAR1 Auto- Regulatory Loop Down-Regulates VEGF in Non-Small Cell Lung Cancer to Restrain Angiogenesis. PLoS One, 9 (6). e99743- e99743.

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Lung cancer is the leading cause of cancer-related deaths worldwide. Despite decades of research, the treatment options for lung cancer patients remain inadequate, either to offer a cure or even a substantial survival advantage owing to its intrinsic resistance to chemotherapy. Our results propose the effectiveness of capsaicin in down-regulating VEGF expression in nonsmall cell lung carcinoma (NSCLC) cells in hypoxic environment. Capsaicin-treatment re-activated p53-SMAR1 positive feedback loop in these cells to persuade p53-mediated HIF-1a degradation and SMAR1-induced repression of Cox-2 expression that restrained HIF-1a nuclear localization. Such signal-modulations consequently down regulated VEGF expression to thwart endothelial cell migration and network formation, pre-requisites of angiogenesis in tumor micro-environment. The above results advocate the candidature of capsaicin in exclusively targeting angiogenesis by down-regulating VEGF in tumor cells to achieve more efficient and cogent therapy of resistant NSCLC.

Item Type: Article
Subjects: Cancer Biology
Depositing User: Mr. Rameshwar Nema
Date Deposited: 15 Apr 2015 09:24
Last Modified: 30 Jun 2015 09:37
URI: http://nccs.sciencecentral.in/id/eprint/83

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