Sivakrishna , B and Shukla, M and Santra , MK and Pal, S (2020) Design, synthesis and cytotoxicevaluation of truncated 3'-deoxy- 3', 3' difluororibofuranosyl pyrimidinenucleosides. Carbohydrate Research, 497. p. 108113.

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Abstract

Truncated 3'-deoxy- 3', 3' difluororibofuranosyl pyrimidine nucleoside derivatives were synthesized from d-ribose via β-apioribo pyrimidine nucleoside intermediates 11a-c. The synthetic approach signifies that truncation at C3' position of apioribose ring of 13a-c by oxidative cleavage of diols with Pb(OAc)4 and followed by fluorination with DAST as key steps. Cytotoxic evaluation of synthesized truncated nucleoside derivatives 16a-c and 19a-c were tested against MCF7 and MDA-MB-231 breast cancer cell lines. However, only 19a was shown minimal growth suppression activity on MDA-MB-231 cancer cell lines.

Item Type:	Article
Subjects:	Cancer Biology
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	07 Feb 2021 13:01
Last Modified:	07 Feb 2021 13:01
URI:	http://nccs.sciencecentral.in/id/eprint/894

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