Dhar , A. and Mallick , S. and Maiti , A. and Ghosh , P. and Ahmed , I. and Bhattacharyya, S. and Mandal , T. and Manna , A. and Singh , S. and Nayak , D. and Wilder , P. and Markowitz , J. and Weber , D. and Ghosh , M. and Chattopadhyay , S. and Guha , R. and Konar , A. and Bandyopadhyay , S. and Roy , S. (2014) Simultaneous Inhibition of Key Growth Pathways in Melanoma Cells and Tumor Regression by a Designed Bidentate Constrained Helical Peptide. Biopolymers. , 101 (4). pp. 344-358.

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Abstract

Protein-protein interactions are part of a large number of signaling networks and potential targets for drug development. However, discovering molecules that can specifically inhibit such interactions is a major challenge. S100B, a calcium-regulated protein, plays a crucial role in the proliferation of melanoma cells through protein-protein interactions. In this article, we report the design and development of a bidentate conformationally constrained peptide against dimeric S100B based on a natural tight binding peptide, TRTK-12. The helical conformation of the peptide was constrained by substitution of

Item Type:	Article
Additional Information:	This Article is Online Free Avaialble go through the above weblink
Subjects:	Cancer Biology
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	22 Apr 2015 06:43
Last Modified:	30 Jun 2015 10:01
URI:	http://nccs.sciencecentral.in/id/eprint/90

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