Kumar, S and Paul, D and Bhushan, B and Wakchaure, GC and Meena, KK and Schouche, Y (2020) Traversing the “Omic” landscape of microbial halotolerance for key molecular processes and new insights. Critical Review in Immunology , 46 (6).

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Abstract

Post-2005, the biology of the salt afflicted habitats is predominantly studied employing high throughput “Omic” approaches comprising metagenomics, transcriptomics, metatranscriptomics, metabolomics, and proteomics. Such “Omic-based” studies have deciphered the unfamiliar details about microbial salt-stress biology. The MAGs (Metagenome-assembled genomes) of uncultured halophilic microbial lineages such as Nanohaloarchaea and haloalkaliphilic members within CPR (Candidate Phyla Radiation) have been reconstructed from diverse hypersaline habitats. The study of MAGs of such uncultured halophilic microbial lineages has unveiled the genomic basis of salt stress tolerance in “yet to culture” microbial lineages. Furthermore, functional metagenomic approaches have been used to decipher the novel genes from uncultured microbes and their possible role in microbial salt-stress tolerance. The present review focuses on the new insights into microbial salt-stress biology gained through different “Omic” approaches. This review also summarizes the key molecular processes that underlie microbial salt-stress response, and their role in microbial salt-stress tolerance has been confirmed at more than one “Omic” levels.

Item Type:	Article
Subjects:	Infection and Immunity
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	07 Feb 2021 13:39
Last Modified:	07 Feb 2021 13:39
URI:	http://nccs.sciencecentral.in/id/eprint/900

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