Kumar , CMS (2016) Drug resistance in malaria. In Antibiotic Resistance. In: Drug Resistance in Bacteria, Fungi, Malaria, and Cancer. Drug Resistance in Bacteria, Fungi, Malaria, and Cancer pp 429-447 . Springer, pp. 429-447.

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Abstract

Malaria is one of the most prevalent and most fatal parasitic disease humans with 1–2 million fatalities every year. Although intense efforts to eradicate malaria are progressing with several treatment regimens, emergence of drug-resistant parasites impedes these efforts. Resistance has emerged to all the mainstream antimalarial drugs including the artemisinin and therefore is responsible for an immense increase in malaria-related mortality worldwide, particularly in Africa. Fortunately, inherent emergence of resistance has been effectively prevented by the combinatorial antimalarial drugs such as the artemisinin derivative combinations. Therefore, sustained improvements in antimalarial medicines with comprehensive understanding of the mechanism of action and resistance are essential to treat and control malaria. This chapter presents the current understanding on the mechanism of the evolution of drug resistance and the strategies followed to delay or curtail it.

Item Type:	Book Section
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	23 Dec 2021 11:06
Last Modified:	23 Dec 2021 11:06
URI:	http://nccs.sciencecentral.in/id/eprint/901

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