Haldar , S. and Kumar , S. and Kolet , S.P. and Patil , H.S. and Kumar , D. and Kundu , G.C. and Thulasiram , H.V. (2013) One-Pot Fluorescent Labeling Protocol for Complex Hydroxylated Bioactive Natural Products. Journal of Organic Chemistry, 78. pp. 10192-10202.

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Abstract

Tagging of small bioactive molecules with a fluorophore is a highly sensitive method to trace their cellular activities through real-time visual information. Here we disclose a 7-nitrobenzo-2-oxa-1,3-diazole (NBD)-based, highyielding, one-pot labeling protocol for hydroxylated molecules using Yamaguchi coupling as the key reaction. This methodology was successfully applied on several sensitive and complex hydroxylated bioactive compounds including 7-deacetylazadiradione, simvastatin, camptothecin, andrographolide, cinchonine, β-dihydroartemisinin, and azadirachtin A. Further, utility of this protocol was illustrated on the cytotoxic activity of azadiradione derivatives against several cancer cell lines through cell imaging of two qualified fluorescent probes.

Item Type:	Article
Additional Information:	This article is Online Free Avaialble go through the above web link
Subjects:	Cancer Biology
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	22 Apr 2015 08:00
Last Modified:	30 Jun 2015 10:52
URI:	http://nccs.sciencecentral.in/id/eprint/93

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