Hegde , S.R. and Pal, K. and Mande , S.C. (2014) Differential enrichment of regulatory motifs in the composite network of protein-protein and gene regulatory interactions. BMC System Biology , 8 (26). pp. 1-8.

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Abstract

Background: An important aspect of molecular interactions is the dynamics associated with growth conditions. Intuitively, not all possible interactions take place together all the time in a cell as only a subset of genes is expressed based on environmental conditions. Results: Large scale gene expression data of Escherichia coli was analyzed to understand the dynamics exhibited at expression level. A large compendium of gene expression datasets, which covers about 466 growth conditions, was used for the analysis. Using gene expression data, genes of E. coli were profiled into three classes: Widely expressed, Conditionally expressed and Rarely expressed. Further, dynamics associated with molecular interactions were analysed by studying changing importance of motifs in the composite networks across growth conditions. Conclusions: Our analysis of large scale gene expression data suggests conditional expression of genes which brings about befitting responses for a given growth environment. We observe a range of importance for network motifs across conditions which can be correlated with a specific function. Our study therefore suggests rewiring of molecular interactions driven by gene expression changes depending on the conditional needs. Keywords: Protein-protein interaction, Gene expression, Motifs, Network, Gene regulation

Item Type:	Article
Subjects:	Structural Biology
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	22 Apr 2015 08:08
Last Modified:	30 Jun 2015 10:53
URI:	http://nccs.sciencecentral.in/id/eprint/94

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