Sharma, S and Mohan, S and Mane, SG and Pote , ST and Patole , MS and Sharma, R (2023) Chapter 16 - Candida: Biofilm formation and antifungal resistance. In: Understanding Microbial Biofilms Fundamentals to Applications. Academic Press Elsevier, pp. 261-273. ISBN 978-0-323-99977-9

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Abstract

Species of Candida are mostly pathogens of humans and animals and cause both systemic and superficial infections. Several antifungal drugs are available to treat the same. However, over the past years, there is an increase in the antifungal drug resistance in the species of yeasts including Candida. As we are aware, one the most important features of Candida is their ability to produce biofilms. These biofilms are known to protect the pathogen from host immune response system and antifungal drugs. The ability of Candida to adhere to different types of metal and plastic surfaces and form biofilm on medical devices such as intravascular catheters, prosthetic heart valves, joint replacements, or any other artificial organ to be used inside the host tissues. This helps in the persistent colonization of the infections. Due to this there has been an increase in the multidrug-resistant infection from hospitals. The book chapter focuses on the factors affecting the biofilm formation, characteristics of biofilm, and recent advances in the area. The whole-genome sequencing has given new insights into the knowledge of biofilm and antifungal drug resistance. The new insights obtained from the whole-genome sequence data for the physiological aspects of the biofilm and antifungal drug resistance are also discussed.

Item Type:	Book Section
Additional Information:	1.SAGE University, Bhopal, Madhya Pradesh, India 2.Banaras Hindu University ,Varanasi, Uttar Pradesh, India 3.National Centre for Microbial Resources (NCMR), Maharashtra, India 4.National Centre for Biological Sciences, Bengaluru, Karnataka, India
Subjects:	Insect Molecular Biology
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	08 Feb 2023 10:47
Last Modified:	08 Feb 2023 10:47
URI:	http://nccs.sciencecentral.in/id/eprint/1245

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