Alai, S and Ghattargi , VC and Gautam, M and Patel, K and Pawar, SP and Dhotre, DP and Shaligram , U and Gairola , S (2020) Comparative genomics of whole-cell pertussis vaccine strains fromIndia. BMC Genomics. 2020 May 7;21(1):345. , 21 (1). p. 345.

Text 90.-1 Dr. Dhotre D. (BMC genomics) NCMR open access.pdf Restricted to Repository staff only Download (2136Kb) | Request a copy

Abstract

Despite high vaccination coverage using acellular (ACV) and whole-cell pertussis (WCV) vaccines, the resurgence of pertussis is observed globally. Genetic divergence in circulating strains of Bordetella pertussis has been reported as one of the contributing factors for the resurgence of the disease. Our current knowledge of B. pertussis genetic evolution in circulating strains is mostly based on studies conducted in countries using ACVs targeting only a few antigens used in the production of ACVs. To better understand the adaptation to vaccine-induced selection pressure, it will be essential to study B. pertussis populations in developing countries which are using WCVs. India is a significant user and global supplier of WCVs. We report here comparative genome analyses of vaccine and clinical isolates reported from India. Whole-genome sequences obtained from vaccine strains: WCV (J445, J446, J447 and J448), ACV (BP165) were compared with Tohama-I reference strain and recently reported clinical isolates from India (BPD1, BPD2). Core genome-based phylogenetic analysis was also performed using 166 isolates reported from countries using ACV.

Item Type:	Article
Subjects:	Insect Molecular Biology
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	21 Jan 2021 09:44
Last Modified:	29 Nov 2021 10:56
URI:	http://nccs.sciencecentral.in/id/eprint/864

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