Kamble , S.C. and Bapat , S.A. (2013) Stem cell and cancer stem cell games on the ECM field. Journal of Cancer Stem Cell Research. e1002-e1002.

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Abstract

Abstract: Stem cell (SC) and cancer stem cell (CSC) regulation is congregated around the dynamic role played by their niche that defines a domain-specific identity and functions. The major macromolecular components of any physiological niche are collectively referred to as Extra Cellular Matrix (ECM). Consequently, niche-determined governance of SC-CSC fate(s) is significantly wired by the ECM and its chemical undercurrents, which involve specific signaling cascades driving asymmetrical division and self-renewal, besides maintaining tissue and organ homeostasis. Cell transformation is often associated with variations in ECM composition and dynamics; although the distinction of whether these are a cause or an effect of the process is not clearly established. CSCs regulate altered ECM subtleties; these in turn support disease progression by providing the necessary cues to maintain CSC quiescence and regeneration yet drive cancer metastases. Further, the specific composition of altered ECM plays a critical role in metastatic dissemination and homing to specific secondary sites for tumor regeneration. The present review presents our understanding of modulation of SC and CSC interactions in their respective niche by ECM components, and a complementary focus of intonation of ECMbiochemistry by these cells in developing an aberrant phenotype

Item Type:	Article
Additional Information:	This is Open Access Journal (for full text click above weblink)
Subjects:	Stem Cell Biology
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	22 Apr 2015 10:08
Last Modified:	01 Jul 2015 05:55
URI:	http://nccs.sciencecentral.in/id/eprint/101

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