Deb, A. and Deshmukh , B. and Ramteke, R. and Bhati , FK. and Bhat, BK. (2021) Resistin: A journey from metabolism to cancer. Translational Oncology, 14 (10). 101178 .

Text 52.-1.Dr. Bhat MK (Tranlation Oncology) open access.pdf Restricted to Repository staff only Download (3605Kb) | Request a copy

Abstract

Resistin, a small secretory molecule, has been implicated to play an important role in the development of insulin resistance under obese condition. For the past few decades, it has been linked to various cellular and metabolic functions. It has been associated with diseases like metabolic disorders, cardiovascular diseases and cancers. Numerous clinical studies have indicated an increased serum resistin level in pathological disorders which have been reported to increase mortality rate in comparison to low resistin expressing subjects. Various molecular studies suggest resistin plays a pivotal role in proliferation, metastasis, angiogenesis, inflammation as well as in regulating metabolism in cancer cells. Therefore, understanding the role of resistin and elucidating its’ associated molecular mechanism will give a better insight into the management of these disorders. In this article, we summarize the diverse roles of resistin in pathological disorders based on the available literature, clinicopathological data, and a compiled study from various databases. The article mainly provides comprehensive information of its role as a target in different treatment modalities in pre as well as post-clinical studies.

Item Type:	Article
Subjects:	Cancer Biology
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	24 Nov 2021 07:18
Last Modified:	26 Nov 2021 11:44
URI:	http://nccs.sciencecentral.in/id/eprint/1064

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