Singh , DK and Shivalingappa , PKM and Sharma, A and Mondal , A and Muzumdar, D and Shiras, A and Bapat , SA (2022) NSG-70, a new glioblastoma cell line with mixed proneural-mesenchymal features associates NOTCH1-WNT5A signaling with stem cell maintenance and angiogenesis. Journal of Neuro-Oncology, 157 (3). pp. 575-591.

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Abstract

Glioblastoma initiation and progression is believed to be driven by Glioma stem cells (GSCs). Activation of NOTCH1 and WNT, and more recently, non-canonical WNT5A signaling, has been demonstrated to regulate self-renewal and differentiation of the GSCs crucially. High expression levels of NOTCH1 and WNT in GBM tumors contribute to the sustenance of GSCs and mediate characteristic phenotypic plasticity, which is reflected by the different subtypes and tremendous intra-tumor heterogeneity. However, the coregulation of NOTCH1 and WNT5A is not well understood. Here, we studied the role of these molecules in regulating the characteristics of different GSC subtypes.

Item Type:	Article
Additional Information:	1. ExoCan Healthcare Technologies Pvt Ltd, Lab 4, 400-NCL Innovation Park, Dr. Homi Bhabha Rd, Pune, India. 2. Department of Neurosurgery, King Edward Memorial Hospital, Parel, Mumbai, 400 012, India. 3. National Centre for Cell Science, Savitribai Phule Pune University, Ganeshkhind, Pune, 411007, India (Corresponding Author)
Subjects:	Cancer Biology
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	18 Oct 2022 07:20
Last Modified:	18 Oct 2022 07:28
URI:	http://nccs.sciencecentral.in/id/eprint/1166

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